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**Predicted scores and comprehensive game-by-game analyses for MLS Week 29 (Wednesday October 21 – Sunday October 25, 2026; all times ET).**
Standings as of mid-to-late October 2026: **Nashville SC** lead the East (and league) on 67 points; **Vancouver Whitecaps** lead the West on 55 points. Inter Miami, New England, St. Louis, Dallas, and Chicago remain strong. Lower-table sides (Sporting KC, Montréal, Atlanta) continue to struggle.
### Wednesday, October 21
**FC Cincinnati (≈36 pts, mid East) vs. D.C. United (≈33 pts, mid-lower East) — 7:00 PM, TQL Stadium**
Even mid-table East clash. Cincinnati have more attacking output at home; D.C. have been resilient but inconsistent. Slight home edge in a tight contest.
**Prediction: Cincinnati 2–1 D.C. United**
### Saturday, October 24
**CF Montréal (≈25 pts, 15th East) vs. Nashville SC (≈67 pts, 1st East) — 1:30 PM, Stade Saputo**
Major mismatch. Nashville are the league’s most complete side with elite defense and attack. Montréal sit at the bottom. Expect controlled away dominance.
**Prediction: Montréal 0–3 Nashville**
**Columbus Crew (≈35 pts, lower East) vs. Toronto FC (≈36 pts, mid East) — 3:30 PM, ScottsMiracle-Gro Field**
Even mid-to-lower East game. Columbus at home have a modest edge; both sides have been inconsistent. Tight, low-scoring contest likely.
**Prediction: Columbus 1–1 Toronto**
**New York Red Bulls (≈36 pts, mid East) vs. Inter Miami CF (≈55 pts, 2nd East) — 5:30 PM, Sports Illustrated Stadium**
Miami have superior star power and sit firmly in the top tier. NYRB at home can compete but face a significant quality gap. Away favorites.
**Prediction: NY Red Bulls 1–2 Inter Miami**
**Atlanta United (≈30 pts, lower East) vs. Chicago Fire (≈48 pts, 4th East) — 7:30 PM, Mercedes-Benz Stadium**
Chicago are more consistent and higher in the table. Atlanta near the bottom. Clear away quality edge.
**Prediction: Atlanta 1–2 Chicago**
**D.C. United (≈33 pts) vs. FC Cincinnati (≈36 pts) — 7:30 PM, Audi Field**
Reverse fixture of Wednesday’s game (or potential schedule listing). Even matchup; home advantage gives D.C. a slight lean in a competitive East clash.
**Prediction: D.C. United 1–1 Cincinnati**
**Orlando City SC (≈41 pts, 7th East) vs. New York City FC (≈34 pts, mid East) — 7:30 PM, Inter&Co Stadium**
Orlando have shown better recent home form. NYCFC inconsistent on the road. Home edge.
**Prediction: Orlando 2–1 NYCFC**
**Philadelphia Union (≈46 pts, 6th East) vs. New England Revolution (≈52 pts, 3rd East) — 7:30 PM, Subaru Park**
Strong East mid/upper-table clash. New England are more consistent overall; Philly solid at home. Competitive with a slight away lean.
**Prediction: Philadelphia 1–2 New England**
**Colorado Rapids (≈39 pts, mid West) vs. Vancouver Whitecaps (≈55 pts, 1st West) — 8:30 PM, Dick’s Sporting Goods Park**
Vancouver lead the West with elite metrics. Colorado at home can be competitive but face a clear step up. Away favorites.
**Prediction: Colorado 1–2 Vancouver**
**FC Dallas (≈51 pts, 3rd West) vs. San Jose Earthquakes (≈48 pts, 4th West) — 8:30 PM, Toyota Stadium**
High-quality Western Conference matchup. Dallas strong at home; San Jose consistent. Tight game with a home lean.
**Prediction: Dallas 2–1 San Jose**
**Houston Dynamo (≈47 pts, 5th West) vs. Minnesota United (≈34 pts, lower West) — 8:30 PM, Shell Energy Stadium**
Houston are organized and consistent. Minnesota struggle for results. Clear home favorites.
**Prediction: Houston 2–0 Minnesota**
**Real Salt Lake (≈36 pts, mid West) vs. St. Louis CITY SC (≈51 pts, 2nd West) — 8:30 PM, America First Field**
St. Louis are one of the West’s strongest sides. RSL at home but underdogs. Away quality edge.
**Prediction: Real Salt Lake 1–2 St. Louis**
**Sporting Kansas City (≈22 pts, 15th West) vs. Austin FC (≈31 pts, mid-lower West) — 8:30 PM, Sporting Park**
SKC remain the league’s weakest. Austin have more quality. Away win expected.
**Prediction: Sporting KC 0–2 Austin**
**Portland Timbers (≈34 pts, mid West) vs. Charlotte FC (≈47 pts, 5th East) — 10:30 PM, Providence Park**
Charlotte sit higher and are more consistent. Portland at home can compete. Slight away lean.
**Prediction: Portland 1–2 Charlotte**
**San Diego FC (≈34 pts, mid West) vs. Seattle Sounders (≈42 pts, 7th West) — 10:30 PM, Snapdragon Stadium**
Seattle are more solid overall. San Diego at home keep it competitive. Slight away edge.
**Prediction: San Diego 1–2 Seattle**
### Sunday, October 25
**LAFC (≈46 pts, 6th West) vs. LA Galaxy (≈40 pts, mid West) — 9:00 PM, BMO Stadium**
El Tráfico. LAFC have superior structure and home form. Galaxy capable but underdogs in the derby.
**Prediction: LAFC 2–1 LA Galaxy**
### Summary of Predicted Scores
- Cincinnati 2–1 D.C. United
- Montréal 0–3 Nashville
- Columbus 1–1 Toronto
- NY Red Bulls 1–2 Inter Miami
- Atlanta 1–2 Chicago
- D.C. United 1–1 Cincinnati
- Orlando 2–1 NYCFC
- Philadelphia 1–2 New England
- Colorado 1–2 Vancouver
- Dallas 2–1 San Jose
- Houston 2–0 Minnesota
- Real Salt Lake 1–2 St. Louis
- Sporting KC 0–2 Austin
- Portland 1–2 Charlotte
- San Diego 1–2 Seattle
- LAFC 2–1 LA Galaxy
**Key themes:** Nashville and Vancouver continue as the clearest favorites. Strong home sides (Houston, Dallas, Orlando, LAFC) and clear mismatches (Montréal–Nashville, SKC–Austin) dominate. Several mid-table games lean toward one-goal margins. Predictions based on current form, standings, home advantage, and quality gaps as of mid-October 2026.